Targeted drug delivery with focused ultrasound-induced blood-brain barrier opening using acoustically-activated nanodroplets
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Targeted Drug Delivery with Focused Ultrasound-Induced Blood-Brain Barrier Opening Using Acoustically-Activated Nanodroplets
Objective – Focused ultrasound (FUS) in the presence of systemically administered microbubbles has been shown to locally, transiently and reversibly increase the permeability of the blood-brain barrier (BBB), thus allowing targeted delivery of therapeutic agents in the brain for the treatment of central nervous system diseases. Currently, microbubbles are the only agents that have been used to ...
متن کاملLipid microbubbles as a vehicle for targeted drug delivery using focused ultrasound-induced blood-brain barrier opening.
Focused ultrasound in conjunction with lipid microbubbles has fully demonstrated its ability to induce non-invasive, transient, and reversible blood-brain barrier opening. This study was aimed at testing the feasibility of our lipid-coated microbubbles as a vector for targeted drug delivery in the treatment of central nervous system diseases. These microbubbles were labeled with the fluorophore...
متن کاملBlood-brain barrier opening-based local delivery of 80 nm-sized liposomes in mice using pulsed focused ultrasound
Background/introduction Continuous focused ultrasound (FUS) has been mostly used to generate high temperatures necessary for tissue ablation. Pulsed FUS in combination with intravenously injected microbubbles has been shown to open the blood-brain barrier (BBB) to increase plasma-to-tissue permeability, thus presenting a new opportunity for local drug delivery to the targeted part of the brain....
متن کاملIn vivo Targeted Drug Delivery to the Brain using MRI Guidance of Focused Ultrasound
Introduction The clinical application of chemotherapy to brain tumors has been severely limited because antitumor agents are typically unable to penetrate an intact blood-brain barrier (BBB). Nonlocalized diffuse opening of the BBB permits drugs to reach the brain but can have dose-limiting side effects. MRI-guided focused ultrasound (FUS) can be applied to the brain to temporarily disrupt the ...
متن کاملBehavioral effects of targeted drug delivery via non-invasive microbubble enhanced focused ultrasound blood brain barrier opening in non-human primates
Background/introduction The Blood Brain Barrier (BBB) in Non-Human Primates (NHP) can be non-invasively opened through the use of Focused Ultrasound (FUS) in conjunction with microbubbles. This procedure allows for a targeted, transient opening in the BBB of the NHP which can be utilized to facilitate drug delivery. While FUS has been used to deliver various pharmacological compounds to promote...
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تاریخ انتشار 2017